Allergy Screen


Allergic reactions are triggered when allergens interact with already formed antibodies (IgE) bound to certain receptors on specific mast cells. The extent of reaction is dependent on the amount of antigen or allergen as well as the mode of entry into the human system. Once activated, the specific antibody (IgE) induces an inflammatory reaction by releasing chemical mediators and synthesizing leukotrienes and cytokines. Signs and symptoms of allergic reactions range from the irritating sniffles of hay fever when pollen is inhaled, to the life-threatening circulatory collapse that occurs in systemic anaphylaxis also known as anaphylactic shock when some individuals ingest peanuts.

Laboratory Testing: When an individual is suspected of having an allergy, a specific IgE test is requested to help confirm or rule out the suspicion of the allergy. IgE antibody developments can be detected at an early stage, in which case, indicating sensitization, even before clinical signs and symptoms have developed.

In determining allergic reactions to specific substances, (ie, certain specific food items), radioimmunoassay test (RAST) is used to determine the extent of reaction when the individuals blood sample comes into contact with the requested allergen.

Results of testing are categorized in CAP-classes (1-6) and show a good link between the presence of IgE antibody in serum, positive skin or provocation tests (if tested), as well as symptoms of allergy. Positive CAP results to a specific allergen demonstrate specific IgE sensitization but are not proof that the allergen is the cause of clinical symptoms.

As in all diagnostic testing, a definitive clinical diagnosis should not be based solely on the results of a single laboratory test method. However, a diagnosis should be made by the physician after evaluation of all clinical and laboratory findings.

Below are a series of tests that can be selected individually;

  • Inhalation allergen screen
  • Food allergen screen
  • Total IgE
  • Eczema
  • Gastro adult
  • Asthma/ Rhinitis perennial
  • Gastro childs
  • Asthma/ Rhinitis

Source: Synlab Parameters Index, Synlab MVZ Leinfelden, 2016/2017 edition. Version 1.0/1617

There are other advanced tests available upon your doctor’s request. Contact us on 0302 763 580 for further details or booking.

Download this file (synlab_allergy_request.pdf)Download Request Form

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